A preview of Amicus Therapeutics

Amicus Therapeutics is a biopharmaceutical company established in 2002 at Cranbury New Jersey. In 2008, Amicus Therapeutics expanded from its single location site in New Jersey to a second research Centre in San Diego. The biotechnology company seeks to treat a range of rare and orphaned disorders. The company product manufacturing systems are anchored on the chaperone advanced replacement therapy (CHART) integrated to enzyme replacement therapies. Amicus Therapeutics enjoys a robust development pipeline program for the treatment of a wide range of human genetic disorders. Additionally, the company had deployed the latest technologies and medicines to cure people with devastating conditions (https://seekingalpha.com/article/4073303-amicus-therapeutics-small-biotech-seems-big-mo). Further, the company envisions to positively impact on the lives of their clients, with the need of patients with rare diseases being the Centre of their incentive science.




Some of the lead products at Amicus Therapeutics include:

  • Migalastat. A lead product targeted to individuals suffering from Fraby disease, based on genetic diagnosis.
  • SD-101. Though in late stage development, the product is set to treat skin blistering and lesions connected with the rare genetic connective tissue disease Epidermolysis Bullosa (EB).
  • ATB200/AT2221 – a paradigm that encompasses enzyme replacement enzymes and pharmacological chaperone to treat Pompe disease.
  • Novel enzyme replacement therapy meant to cure Fabry disease


Ongoing studies:


At Amicus Therapeutics, studies are underway to provide a unique Enzyme Replacement Therapy for Lysosomal Storage Disorders (Crunchbase). Further, a research team is currently working on a Protein replacement therapy for the CDKL5 deficiency. The CDKL5 deficiency is a disorder that manifests itself right from infancy and if not treated may lead to paralysis, visual impairment, scoliosis, sensory impairment and gastrointestinal complications.




Amicus Therapeutics believe in Ethics and compliance in the execution of their daily activities. Further, the company supports programs aimed at fostering patient care with the provision of medical, scientific and educational data to all stakeholders of the company. As part of their Corporate Social Responsibility (CSR), Amicus Therapeutics offers charitable contributions to disadvantaged members of the community and offers educational grants. When undertaking such activities, high priority is given to individuals with or have their beloved ones suffering from CDKL5 deficiency, Epidermolysis Bullosa, and Lysosomal Storage Disorders.


Amicus Therapeutics Leads The Way In Rare And Orphan Disease Research

Amicus Therapeutics is a leading biotechnology company that supports treatment for rare diseases worldwide. The company’s mission is to research and produce pharmaceuticals to treat rare and orphan diseases known as lysosomal storage disorders. Amicus Therapeutics was privately held by venture capitalists until 2007 when the company became an IPO and publicly traded on the NASDAQ. Their company headquarters are in Cranbury, New Jersey.


John Crowley is the CEO of Amicus Therapeutics and has held this position since 2010 (MarketWatch). John Crowley is a well-respected biotechnology entrepreneur, and is the co-founder of Novazyme Pharmaceuticals. John’s leadership skills have helped focus the business on patient driven success. Every employee at Amicus Therapeutics is dedicated to the improvement of those born with rare or orphan diseases. Their business model embraces ethics, compliance and integrity in everything all parts of the company.


Amicus Therapeutics is one of a handful of biotechnology companies who are developing drugs for a small sector of the population who are affected by lysosomal storage disorders. The company has several important drugs in production: Migalastat is a drug formulated to treat patients with Fabry disease. Fabry disease is a rare genetic disorder in which the human body cannot release fat due to a lack of enzymes in the body. A second drug in production is SD-101, a treatment for the genetic tissue disorder called Epidermolysis Bullosa. Amicus Therapeutics focus is on researching the effectiveness of novel enzyme replacement therapies and biologics,which are genetically engineered proteins processed from human genes.


Orphan diseases are classified by the USDA as diseases that affect less than 200,000 people in the United States (GoogleFinance). Due to the nature of rare and orphan diseases research in this sector has been historically underfunded. Amicus Therapeutics received a financial helping hand in 2010 from the Michael J. Fox Foundation in the form of a grant for $500,000. In the same year Amicus Therapeutics was granted $210,300 from the Alzheimer’s Drug Discovery Foundation. Amicus Therapeutics purchased the biotechnology company Callidus Biopharma in 2013, and Scioderm in 2015. The company continues to grow as they work towards important biotechnology therapies.

Preventing Crimes in the City with Securus Technologies

I am part of an elite task force that has only one objective, finding fugitives and getting then into custody and away from the residents of the city. This month we had our hands full with a suspect who was holding up local businesses at gun point and not afraid to let authorities know that he was not going to back down despite their efforts. We got notification from the suspect via a phone message that if we did not back off, he was going to make innocent people suffer as a result.


On a recent trip to the prison, my team was informed that Securus Technologies was in town updating the inmate phone communication system. I have heard good things about this Dallas-based company and CEO Richard Smith, and our team aligns with the same objective of those 1,000 employees at Securus Technologies, making the world a safer place. Perhaps this was something that could help us in our efforts to get this very dangerous fugitive off the streets and into his very own concrete cell where he wont be able to do anyone hard from now on.


It wasn’t long after the call monitoring system was installed that we started to hear chatter about our suspect. It appears that he made a few enemies along the way, and one inmate was insistent that his family not allow the suspect to use their land to hide. We put in a call immediately to officers that they get to and surround the property immediately. There was no way he would get away if he was anywhere on that property. That tip was key in getting a team to that location and grabbing the suspect in the middle of the night while he was asleep and unaware we had 20 officers armed to the teeth ready to go to war.


Put The Flare Back In Your Hair With Wen Hair Care

We all want healthier, shinier hair, with so many factors that play into the causes of brittle, dry, and breaking hair maintaining a healthy head of hair can be somewhat of a challenge. Factors such as heat, dye, processing all play a role in hair trauma. On the horizon is a new way of getting the flare back in your hair without using the harsh chemicals that comes with using shampoo. Cleansing conditioners are becoming apart of the new healthy way to take care of your hair.

Cleansing Conditioners
Cleansing conditioners also known as co-wash contains a cleansing agent that cleanses the hair. The benefits of using cleansing conditioners include, removes build up, and repairs the hair without using the harsh chemicals that come in detergent based shampoos. As we all know while shampoos does cleanse your hair, it also strips your hair of its natural oils in the process often leaving your hair frizzy or dry. Wen offers a cleansing conditioner that not only repairs the hair, but offers a product that is beneficial to maintaining healthier, shinier, fuller and thicker hair.

Wen Hair was created by celebrity stylist Chaz Dean, as a stylist he is dedicated to providing the best quality hair care for his clients. Chaz Dean overall goal was to find a product that could work for all types of hair. Using only organic based ingredients Chaz created the 5-in-1 cleansing conditioner, a conditioner that not only cleanses the hair but also helps treat damaged ends due to heat damage or dye. Wen no lather formula also works for all types of hair, so whether you have straight, wavy, curly, kinky, or coily hair Wen hair care products will work for you. If your looking to save or maintain your hair, Wen hair care products are helping women everywhere put the flare back in their hair.

A Wedding to Remember with Kim Dao

Kim Dao is a beauty Youtube blogger. She has a vlog called “Wedding with my boyfriend.” It starts out with her riding in the car with her boyfriend. They are headed to a friend’s wedding in Australia. Kim Dao mentions that’s a big reason she went back to Australia. The wedding is around a winery area. It is a nice and hot day, perfect weather for a wedding. They are given huge umbrellas to provide shade from the sun. Kim Dao and her friends all gather in the car to head to the restaurant. They find the gift table and Kim Dao facebook.com puts her card in the gift box. They look at the pictures on the table as well. They go outside and take photos. It is not as hot as before. They go back inside to welcome the bride and groom. The bride is enjoying herself. The cake is shown, it is a 3 layer cake. Kim Dao puts the photo she took with her friends on the photo wall with the rest of the wedding photos. The bride and groom cuts and tastes the cake together. They also share a dance together.


Kim Dao myinterviews.com.au is at her boyfriend’s house. They are about to go to sleep because they are tired from the wedding. They both agree that the wedding was fun. Kim Dao says it was nice seeing her high school friend again. She loves weddings. Her and her boyfriend has plans for the next day. She ends the vlog.


Her Vlog: https://youtu.be/RmXhczA5e7Y


How Mike Baur Accelerates the growth of Swiss ICT Startups

Mike Baur is recognized for being the proprietor of an innovative enterprise that is known as the Swiss Startup Factory. He serves the company as its managing partner and has been striving ensure that it offers excellent services to startups that are based in Switzerland. Mr. Baur also has a wealth of experience in the private banking field and had served it for about a decade before venturing into business. Some of the banks that he used to work for are UBS and Clariden Leu. Mike left the banking sector in 2014 and founded the Swiss Startup Factory. He collaborated with Max Meister and Oliver Walzer in establishing the firm. The primary goal of setting up the enterprise was to offer financial and motivational support to talented entrepreneurs growing their businesses into top corporations.


Baur was one of the individuals who was appointed to serve on the jury of the START Summiteer that was hosted at the University of St Gallen. The summit served as a contest of various startups in Switzerland. Mike has been striving to assist young entrepreneurs in penetrating the corporate world. He assists them in accessing capital and also advises them on how they can kick start their enterprises. The Swiss Startup Factory is currently in partnership with CTI and Baur was appointed to serve as CTI Invest’s deputy managing director. He has been running an acceleration program for startup businesses since 2016. The plan is funded by Goldbach Group and the Swiss Startup Factory.


Mike Baur’s career in the banking sector played a great role in the success of his entrepreneurship journey. He once worked as a commercial apprentice at UBS. Mike worked hard and rose through the ranks to become an executive member of one of the top Swiss private banking institutions. During his time as banking professional, he managed to create links with various business leaders who are currently supporting his company. Baur has managed to grow the Swiss Startup Factory due to the passion that he has developed in the supporting potential entrepreneurs. The Swiss Startup Factory is currently the top privately financed ICT startup accelerator in Switzerland. Mike has been working with various investors to raise sufficient funds for running the acceleration programs. He also makes sure that his financing partners invest their money in businesses that can offer them significant returns in the long run.


Do Good Institute, Creating the Next Generation of Non-Profit Entrepreneurs

Do Good Institute, at the University of Maryland, is an unprecedented approach to expose undergraduate students to the world of non-profit and volunteering. The goal is to create a new wave of non-profit business leaders.

Former Atlanta Hawks owner Bruce Levenson took the initiative to the University and seeded $75 million with his wife Karen. His motive is to provide opportunities to the students who are passionate about community service and helping people. The goal is to provide them with necessary skills and competitiveness to be successful in philanthropy as is needed in all businesses.

Since launched in 2010, the initiative has gained tremendous momentum and for the Fall of 2017, majoring in the field is offered. In a report by PR News, the program has already generated a group of non-profit organizations created by former students. It is fulfilling its mission to transform the campus into a Do Good campus where every student is motivated to give back.

It also may change the landscape of a higher education. Virtually all courses can be offered online (brucelevenson.com), which can make the on-campus higher education model obsolete. According to Levenson, Do Good Institute is giving a real reason for 21st century model of campus learning to exist. He wishes to make the Institute as a template so that other schools could replicate. He truly believes that it will be transformational and other campuses will follow the trend.

Bruce Levenson is a co-founder of United Communications Group and has been active in various philanthropic organizations throughout his career.

Read More: http://www.espn.com/nba/story/_/id/11493472/jason-whitlock-bruce-levenson-atlanta-hawks

The U.S. Money Reserve Has a New Website

The biggest private distributor of platinum, silver, and gold products in the U.S and elsewhere, the U.S. Money Reserve was created in 2001 and is located in Austin, Texas. It is easy to diversify assets through the purchase of precious metals. U.S. coins made with the precious metals of gold and silver are the most popular product to own across The United States.

The U.S. Money Reserve has trained highly qualified people to research the market of precious metals and find the most profitable items available. They offer high standards in customer service with the intention of building strong and lasting relationship with their customers.

PR Newswire revealed that the US Money Reserve has added some new features and redesigned their website to accommodate their customers better. Their new website reflects their leadership within the industry of precious metals. A new photo gallery of the precious coins is currently available and photography of Philip N. Diehl, the former U.S. Mint Director, now President of the U.S. Money Reserve.


The new and improved website now has features that will encourage their customers to seek education on the precious metal industry. This will make their customers experience in purchasing bullion a more exciting and lucrative investment for their current and future collections.

With their fully secured online storefront, customers of the U.S Money Reserve will be offered a quality platform of information that is updated regularly with current news and precious metal communications. With this new and improved platform, clients will receive a faster response time from customer service. Education on important events concerning the precious metal industry will be available at the convenience of their customer.

Competitive pricing on their precious metal products is available live. Gold and silver coins as well as bars can be purchased through the website on a safe and secure system. Learn more about U.S. Money Reserve: http://www.prnewswire.com/news-releases/us-money-reserve-featured-on-epns-enterprise-radio-300213820.html

Exclusive products are also available on occasion. An information kit on gold is being offered for free to anyone looking for more information on what to buy and what it can be worth in the future. The most recent information on precious metals and the industry will be included inside the kit, but also through the Knowledge Center link within the website.

Karl Heideck: Respected Pennsylvanian And Legal Expert

Legal Expert Karl Heideck
Legal Expert Karl Heideck

Litigation’s official definition is “the process of taking legal action”. While this sounds simple enough, those who’ve been involved in a lawsuit likely understand that it’s actually a rather rigorous process.

From filing countless papers to responding to official court orders and developing a legally supported argument to conducing ample research, each lawsuit’s build up to an all-powerful settlement or verdict is taxing to say the least. That’s why anyone involved in litigation, as well as anyone who may become involved in litigation at a later point, needs an expert attorney in their corner to guide them through the process and maximize the chances of success.

An expert attorney like Philadelphia’s Karl Heideck.

A graduate from Temple University, one of the most respected colleges in America, as well as the equally noteworthy James E. Beasley School of Law, Karl Heideck has accumulated ample legal experience while assisting a wide variety of clients with often-complex matters. Karl Heideck’s acute and all-encompassing knowledge of precedent and the legal process is rivaled only by his dedication to clients and his insurmountable work ethic.

Specializing specifically in litigation, compliance, and risk management review, Karl Heideck has emerged as one of Pennsylvania’s most prominent and respected attorneys. Truthfully, he is loved by his clients, admired by his peers, and considered a cornerstone of Philadelphia culture by each of the many individuals he knows.

There’s accordingly never been a better time to get in touch with Karl Heideck, to benefit from his assistance, and to be well-assisted in detailed and convoluted legal matters that only an experienced and knowledgeable person like himself can effectively deal with.

Follow Karl Heideck on Twitter.

Why More People are Studying Kabbalah Today

Several Hollywood stars showed interested in the Kabbalah Centre at one point. This is because of Madonna and the commitment that she had shown to the center. The teachings of Kabbalah transformed Madonna. She opened a Kabbalah Center. Some of the celebrities who were influenced by Madonna’s decision included Britney Spears, the late Elizabeth Taylor, the late Marilyn Monroe, and Paris Hilton. People wondered why the Jewish teachings had led many individuals to take it up and even convert to Judaism.

Paris Hilton told the More Magazine that she would not have made it through her breakup with Nick Carter if she had not gone to the Kabbalah Center in Los Angeles immediately. Hilton said that she went there often and was able to cope with life because of it. The Los Angeles Times interviewed Sandra Bernhard. She stated that Kabbalah removed the chaos in her life. The website of the Kabbalah Center describes the teachings as wisdom that gives one the tools to experience, fulfillment, and joy. It goes on to say that the students get the deepest insights into God’s essence and the purpose of creation. It provides a structure of the universe and an understanding of the events in our lives.

The late Sammy Davis said that he joined the Kabbalah Centre because he wanted to experience the ancient culture. Sammy hoped that this would help him to find inner strength and meaning in life. Kabbalah led the late Elizabeth Taylor to convert to Judaism, support the Simon Wiesenthal Center, and become an advocate for Israel. The history of the Kabbalah Center began in 1922 when Rav Yehuda Ashlag decided to bring Kabbalah to the United States. Rav Yehuda passed the torch to Rav Brandwein after he died. Rav Brandwein was succeeded by Rav Berg.

The headquarters of the Kabbalah Center is in Los Angeles. It has numerous centers worldwide. This is in line with their mission of spreading the teachings of Kabbalah to the whole world. The Kabbalah Center is involved in charitable initiatives. It has supported the victims of calamities by providing relief aid.